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InhibitingthecoregulatorCoRESTimpairsFoxp3+Tregfunctionandpromotesantitumorimmunity

JClinInvest,

RESTcorepressor1(Rcor1orCoREST)isaproteinthatbindstotheC-terminaldomainofRESTandregulatesdiverseimmuneandinflammatoryresponses.Inthispaper,theauthorsfoundthatgenedeletionorpharmacologicinhibitiondisruptedFoxp3-dependentrecruitmentoftheCoREST